Product Description

Acinus (Phospho-S1180) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS64570-50, BS64570-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Acinus (apoptotic chromatin condensation inducer in the nucleus) is a caspase substrate that has been implicated in nuclear changes during apoptosis. Chromatin condensation and DNA fragmentation are both nuclear morphological features associated with apoptosis. Acinus is expressed in different isoforms (L, S, S') most likely generated by alternative splicing. During apoptosis Acinus is cleaved by caspase-3 to generate a 23 kDa fragment that was reported to induce chromatin condensation. Acinus has been identified to be a component of the spliceosome complex, ASAP, suggesting a role in pre-mRNA processing. Down regμlation of Acinus by RNA interference inhibits cell growth (5). This study also found that loss of Acinus inhibits DNA fragmentation but not chromatin condensation during apoptosis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Apoptotic chromatin condensation inducer in the nucleus, Acinus, ACIN1, ACINUS, KIAA0670, SR-related and CTD-associated factor 4, CTD-binding SR-like protein RA4, Splicing factor, arginine/serine-rich 15, SCAF4, KIAA1172, SFRS15, Arginine/serine-rich protein PNISR, PNN-interacting serine/arginine-rich protein, SR-related protein, SR-rich protein, Serine/arginine-rich-splicing regμlatory protein 130, SRrp130, Splicing factor, arginine/serine-rich 130, Splicing factor, arginine/serine-rich 18, PNISR, C6orf111, SFRS18, SRRP130, HSPC261, HSPC306, RNA-binding protein 39, CAPER alpha, CAPERalpha, Hepatocellμlar carcinoma protein 1, RNA-binding motif protein 39, RNA-binding region-containing protein 2, Splicing factor HCC1, RBM39, HCC1, RNPC2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human Acinus around the phosphorylation site of Serine 1180.

Dilution: WB:1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Acinus (Phospho-S1180) polyclonal antibody detects endogenous levels of Acinus protein only when phosphorylated at Ser1180.

Molecular Weight: ~ 210 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UKV3/O95104/Q8TF01/Q14498

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only