Product Description

Acrogranin Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21617-50, RA21617-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease., function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth., function:Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling., PTM:Granulins are disulfide bridged., similarity:Belongs to the granulin family., tissue specificity:In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Granulins (Proepithelin;PEPI) [Cleaved into: Acrogranin, Paragranulin, Granulin-1 (Granulin G), Granulin-2 (Granulin F), Granulin-3 (Granulin B), Granulin-4 (Granulin A), Granulin-5 (Granulin C), Granulin-6 (Granulin D), Granulin-7 (Granulin E)]

Clonality: Polyclonal

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Storage: -20°C/1 year

Human Gene ID: 2896

Human SwissProt Number: P28799

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only