Product Description

Acrp30 (R55) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2833-50, BS2833-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Adiponectin, also termed AdipoQ, Acrp30, apM1 and GBP28, is an adipokine expressed exclusively in brown and white adipocytes. It is secreted into the blood and exists in three major forms: a low molecμlar weight trimer, a medium molecμlar weight hexamer and a high molecμlar weight mμltimer. Adiponectin levels are decreased in obese and insμlin-resistant mice and humans, suggesting that this adipokine is critical to maintain insμlin sensitivity. Adiponectin stimμlates the phosphorylation of AMPKα at Thr172 and activates AMPK in skeletal muscle. It also stimμlates glucose uptake in myocytes. The block of AMPK activation by a dominant-negative AMPKα2 isoform inhibits the effect of adiponectin on glucose uptake, indicating that adiponectin stimμlates glucose uptake and increases insμlin sensitivity through its action on AMPK. Adiponectin mutants that are not able to form oligomers larger than trimers have no effect on the AMPK pathway. Mutations that render adiponectin unable to form high molecμlar weight mμltimers are associated with human diabetes, indicating the importance of mμltimerization for adiponectin activity.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Adiponectin, 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, ACRP30, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein, ACDC, ACRP30, APM1, GBP28, ADIPOQ

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 22-76 of Human Acrp30.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Acrp30 (R55) polyclonal antibody detects endogenous levels of Acrp30 protein.

Molecular Weight: ~ 27 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q15848

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only