Actinin- Alpha2 Monoclonal Antibody - BT-MCA0137

Actinin- Alpha2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0137-50, BT-MCA0137-100

Citations, Manuals and MSDS Available upon request.

Background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

Research Areas: Cancer; Signal transduction; Metabolism

Target Protein: ACTN2

Applications: WB, IF, ICC

Reactivity: Human,Rat,Bovine,Chicken,Dog,Pig,Zebrafish

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Alpha-actinin-2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P35609; Mouse: Q9JI91

Synonyms: ACTN2; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein

GeneID: Human: 88

Research Use Only