Active Caspase-3 Monoclonal Antibody (5E1) - BT-MCA0002

Active Caspase-3 Monoclonal Antibody (5E1)

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-MCA0002-20, BT-MCA0002-50, BT-MCA0002-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Research Areas: Cell Biology; Metabolism; Cancer

Target Protein: CASP3

Applications: IF, ICC, WB, IHC-p

Reactivity: Human,Mouse,Rat,Chicken

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Caspase-3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P42574; Mouse: P70677; Rat: P55213

Synonyms: CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1

GeneID: Human: 836

Research Use Only