ACTN1 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-70225-60, E-AB-70225-120, E-AB-70225-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: ACTN1
Target Synonym: actinin 1 smooth muscle; Actinin alpha 1; actinin; alpha 1; ACTN 1; Actn1; ACTN1; Alpha Actinin 1; Alpha actinin cytoskeletal isoform; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; BDPLT15; F actin cross linking protein; F-actin cross-linking protein; FLJ40884; FLJ54432; Non muscle alpha actinin 1; Non-muscle alpha-actinin-1
Research Areas: Cancer, Developmental Biology, Signal Transduction, Stem Cells
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: WB
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P12814,Q7TPR4,Q9Z1P2
Background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
Concentration: 0.66 mg/mL
Immunogen: Recombinant protein corresponding to Mouseα-actinin1
Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Purification Method: Affinity purification
Dilution: WB 1:1000-1:3000
Calculated MW: 102-107kDa
Observed MW: 110kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only