ACTN2 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A3718-20, A3718-100
Citations, Manuals and SDS Available upon request.
Background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms: MPD6; CMH23; CMYP8; CMD1AA; MYOCOZ; ACTN2
GeneID: 88
Swiss-Prot: P35609
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 104kDa
Observed Molecular Weight: 104kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ACTN2 (NP_001094.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Cytoskeleton, Microfilaments, Actins, Immunology Inflammation, T Cell Receptor Signaling Pathway, Cardiovascular, Heart, Contractility, Cardiac arrhythmias
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: SH-SY5Y, HT-29, HeLa, Mouse heart, Mouse skeletal muscle, Mouse lung, Rat liver, Rat heart
Cellular Location: Cytoplasm, Z line, Myofibril, Sarcomere
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.