ACVR1 Polyclonal Antibody - BT-AP06041

ACVR1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP06041-20, BT-AP06041-50, BT-AP06041-100

Citations, Manuals and MSDS Available upon request.

Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins| composed of a ligand-binding extracellular domain with cysteine-rich region| a transmembrane domain| and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding| resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular

Research Areas: Signal transduction; Developmental biology

Target Protein: ACVR1

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Activin receptor type-1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q04771; Mouse: P37172; Rat: P80201

Synonyms: Activin receptor type-1;EC 2.7.11.30;Activin receptor type I;ACTR-I;Activin receptor-like kinase 2;ALK-2;Serine/threonine-protein kinase receptor R1;SKR1;TGF-B superfamily receptor type

GeneID: Human: 90

Research Use Only