ACVR2A Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS65565-50, BS65565-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellμlar domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resμlting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. Activin has been suggested to be an autocrine/paracrine regμlator in the human placenta. The presence of ACVR2 mRNA has been deomnstrated in human trophoblast cells and there is also evidence of expression of the gene in human brain and ovary. Category: Primary Antibody Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB Alternate Names: Activin receptor 2A, Activin receptor type 2A, ACTR 2, ACTR IIA, ACTR2, ActRIIa, Acvr 2, Acvr 2A, Acvr2, Acvr2a, OTTHUMP00000197918, ACVR2A, Activin receptor type-2A. Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH conjugated synthetic peptide derived from mouse ACVR2A:1-100/513 Dilution: WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations shoμld be determined by the end user. Purification: affinity purified by Protein A Specificity: ACVR2A polyclonal Antibody detects endogenous levels of ACVR2A protein. Molecular Weight: ~68kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: P27038 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Research Use Only