ACY1 Polyclonal Antibody - BT-AP14120

ACY1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14120-20, BT-AP14120-50, BT-AP14120-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a cytosolic| homodimeric| zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group| and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1| a region reduced to homozygosity in small-cell lung cancer (SCLC)| and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart| and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency| a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription als

Research Areas: Metabolism; Signal transduction

Target Protein: ACY1

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Aminoacylase-1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q03154; Mouse: Q99JW2

Synonyms: Aminoacylase-1;ACY-1;EC 3.5.1.14;N-acyl-L-amino-acid amidohydrolase

GeneID: Human: 95

Research Use Only