Product Description

ADAM17 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90030-50, BS90030-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P78536(Human) Q9Z0F8(Mouse) Q9Z1K9(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC/IF, IP, , FC

All Applications: WB:1:1,000-1:2,000
FC:1:50-1:100
ICC:1:50-1:200
IP:1:50

Background: Tumor necrosis factor β (TNFβ), also known as lymphotoxin, is a pleiotropic cytokine. TNFα, also known as cachetin, is a cytokine that binds to the same receptors, producing an array of effects similar to those of TNFβ. TNFβ and TNFα share 30% amino acid homology and have similar biological activities. TNFβ is produced by activated lymphocytes, including CD4+ T helper cell type 1 lymphocytes, CD8+ lymphocytes and certain B lymphoblastoid cell lines. TNFα is produced by several different cell types, including lymphocytes, neutrophils and macrophages. TNFβ and TNFα can modulate many immune and inflammatory functions while having the ability to inhibit tumor growth. TACE (for TNFα converting enzyme) is a metalloproteinase that cleaves the membrane-bound TNFα precursor to release soluble TNFα.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: ADAM17 polyclonal antibody detects endogenous levels of ADAM17 protein.

Bioworld Molecular Weight: 93 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of ADAM17 on Jurkat cells lysates using anti-ADAM17 antibody at 1/1,000 dilution., ICC staining ADAM17 in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: ADAM 17, A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), A disintegrin and metalloproteinase domain 17, ADA17, ADAM 17, ADAM metallopeptidase domain 17, ADAM17, ADAM17 protein, CD 156b, CD156b, CD156b antigen, CSVP, Disintegrin and metalloproteinase domain-containing protein 17, MGC71942, NISBD, NISBD1, Snake venom like protease, Snake venom-like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme, TNF-alpha convertase, TNF-alpha-converting enzyme, Tumor Necrosis Factor Alpha Converting Enzyme,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified