ADAMTS13 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90031-50, BS90031-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q76LX8(Human)
Host: Rabbit
Reactivity: Human
Applications: WB, IHC FC
All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100
Background: ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting. It is secreted in blood and degrades large vWf multimers, decreasing their activity. Glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: ADAMTS13 polyclonal antibody detects endogenous levels of ADAMTS13 protein.
Bioworld Molecular Weight: Predicted band size 154 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of ADAMTS13 on SiHa cell (1), PC-3M cell (2) and A549 cell lysates using anti-ADAMTS13 antibody at 1/500 dilution., Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-ADAMTS13 antibody. Counter stained with hematoxylin.
Alternative Name: ADAM-TS 13, ADAM-TS13, ADAMTS-13, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8, A disintegrin and metalloproteinase with thrombospondin motifs 13, A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13, A disintegrin like and metalloprotease with thrombospondin type 1 motif 13, ADAM metallopeptidase with thrombospondin type 1 motif 13, ADAM TS, ADAM-TS 13, ADAM-TS13, ADAMTS 13, ADAMTS-13, ADAMTS13, ADAMTS13 protein, ATS13, C9orf8, TTP, Von Willebrand factor cleaving protease, von Willebrand factor-cleaving protease, vWF cleaving protease, vWF CP, vWF-cleaving protease, vWF-CP, vWFCP,
Immunogen: Recombinant protein within human ADAMTS13 aa 150-350.
Conjugate: Unconjugated
Modification: Unmodified