Product Description

ADAMTS18 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60769-50, BS60769-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modμles) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of thrombospondin 1 (TSP 1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver. ADAMTS-18 is a secreted protein that is also expressed in adμlt brain, endothelium, prostate and submaxillary gland. ADAMTS-18 has two known splice variants and it is structurally most similar to ADAMTS-16. ADAMTS-18 is downregμlated in carcinoma cell lines by methylation of its promoter. Forced expression of ADAMTS-18 in carcinoma cells can lead to significant inhibition of cell growth, suggesting that it plays a significant role as a tumor suppressor.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: A disintegrin and metalloproteinase with thrombospondin motifs 18, ADAM-TS 18, ADAM-TS18, ADAMTS-18, ADAMTS18

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human ADAMTS18

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: ADAMTS18 polyclonal antibody detects endogenous levels of ADAMTS18 protein.

Molecular Weight: ~ 135 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8TE60

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only