Product Description

ADAR2 (R510) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2026-50, BS2026-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ADAR2, also designated adenosine deaminase, RNA-specific (RED1), RNA-editing enzyme 1, DRABA2, DRADA2, ADAR2α-L1, ADAR2α-L2 and ADAR2α-L3, mediates RNA editing by destabilizing RNA through deamination of adenosine to inosine. ADAR2 is responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. It can modify its own pre-mRNA and generate new splice sites. Translocation of endogenous ADAR2 from the nucleolus to the nucleoplasm resμlts in increased editing of endogenous ADAR2 substrates. Alternative splicing of this gene resμlts in several transcript variants that may influence RNA editing. RNA editing involves the deamination of adenosines at specific sites, the resμlt of which can be a change in the amino acid sequence of the protein so that it differs from that predicted by the sequence of the DNA.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: ADARB1, RNA-editing deaminase 1, ADAR2, DRADA2, RED1, dsRNA adenosine deaminase, Double-stranded RNA-specific editase 1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 480-530 of Human ADAR2.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: ADAR2 (R510) polyclonal antibody detects endogenous levels of ADAR2 protein.

Molecular Weight: ~ 82 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P78563

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only