ADCK5 Polyclonal Antibody - BT-AP00256

ADCK5 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP00256-20, BT-AP00256-50, BT-AP00256-100

Citations, Manuals and MSDS Available upon request.

Background: CABC1 (chaperone activity of bc1 complex-like), also known as COQ8 or ADCK3 (aarF domain-containing protein kinase 3) is a 647 amino acid mitochondrial protein that belongs to the ADCK protein kinase. Ubiquitously expressed with higher expression in heart and skeletal muscle, CABC1 is thought to function as a chaperone in the proper assembly of protein complexes found in the respiratory chain. CABC1 expression is induced both in response to DNA damage and by the tumor suppressor p53. When CABC1 expression is inhibited, p53-induced apoptosis is partially suppressed, suggesting a possible role for CABC1 in tumor suppression. Mutations in the gene encoding CABC1 may be implicated in ubiquinone deficiency which can lead to cerebellar ataxia and seizures. Four isoforms of CABC1 exist due to alternative splicing events. Other members of the ADCK protein kinase family include ADCK1, ADCK2, ADCK4 and ADCK5.

Research Areas: Others

Target Protein: ADCK5

Applications: WB, IF, ELISA

Reactivity: Human

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: ADCK5 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 65897

UniProt Accession: Human: Q3MIX3; Mouse: Q80V03

Synonyms: ADCK5; Uncharacterized aarF domain-containing protein kinase 5

GeneID: Human: 203054

Research Use Only