Adrenocorticotropin (ACTH) Polyclonal Antibody - RA21699

Adrenocorticotropin (ACTH) Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21699-50, RA21699-100

Citations, Manuals and MSDS Available upon request.

Background: proopiomelanocortin (POMC) Homo sapiens This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. The

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC-p 1:50-200, WB 1:500-2000

Alternative Names: Pro-opiomelanocortin (POMC;Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH) ; Potential peptide; Corticotropin (Adrenocorticotropic hormone;ACTH) ; Melanotropin alpha (Alpha-MSH) ; Corticotropin-like intermediary peptide (CLIP) ; Lipotropin beta (Beta-LPH) ; Lipotropin gamma (Gamma-LPH) ; Melanotropin beta (Beta-MSH) ; Beta-endorphin; Met-enkephalin]

Applications: IHC-p; IF (paraffin section) ; WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 5443

Protein MW (KDa): 57

SWISS: P01189

Source: Rabbit

Research Use Only