AF/LE Purified Anti-Human CD279/PD-1 Antibody [J116] - E-AB-F11290

AF/LE Purified Anti-Human CD279/PD-1 Antibody [J116]

Sizes: 500μg, 1mg

Catalogue Numbers: E-AB-F11290-500, E-AB-F11290-1

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD279/PD-1

Target Synonym: PD-1, Programmed Death-1,

Conjugation: None (Purified antibody-Azide Free/Low endotoxin)

Host: Mouse

Species Reactivity: Human

Application: FCM,Block,Neut

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Isotype: Mouse IgG1, κ

Clone No.: J116

UNIProt ID: Q15116

Background: Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Concentration: 0.5 mg/mL

Control Catalogue Number: E-AB-F097930

Buffer: 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

Gene ID: 5133

Storage: This product can be stored at 2-8°C for 12 months. Do not freeze.

Shipping: Ice bag

Research Use Only