AF/LE Purified Anti-Human CD8a Antibody [OKT-8] - E-AB-F11100

AF/LE Purified Anti-Human CD8a Antibody [OKT-8]

Sizes: 500μg, 1mg

Catalogue Numbers: E-AB-F11100-500, E-AB-F11100-1

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD8

Target Synonym: T-cell surface glycoprotein CD8 alpha chain, CD8A, T-lymphocyte differentiation antigen T8/Leu-2, MAL,

Conjugation: None (Purified antibody-Azide Free/Low endotoxin)

Host: Mouse

Species Reactivity: Human

Application: FCM,Depletion

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Isotype: Mouse IgG2a, κ

Clone No.: OKT-8

UNIProt ID: P01732

Background: CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

Concentration: 0.5 mg/mL

Control Catalogue Number: E-AB-F098030

Buffer: 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

Gene ID: 925

Storage: This product can be stored at 2-8°C for 12 months. Do not freeze.

Shipping: Ice bag

Research Use Only