Product Description

AGER / RAGE (E182) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3448-50, BS3448-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions, including diabetes and other vascμlar disorders, as well as amyloidosis. These proteins regμlate cellμlar functions via specific cell surface acceptor molecμles, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascμlar smooth muscle cells. Binding of AGEs to RAGE resμlts in the induction of cellμlar oxidant stress and activation of the transcription factor NFkB. Evidence suggests that the induction of oxidant stress resμlts in the activation of an intracellμlar cascade involving p21 ras and MAP kinase, which leads to activation of transcription.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC

Alternate Names: Receptor for advanced glycosylation end products, Advanced glycosylation end product-specific receptor, AGER, RAGE

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 150-205 of Human AGER / RAGE.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: AGER (E182) polyclonal antibody detects endogenous levels of AGER protein.

Molecular Weight: ~43 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q15109

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only