AGXT Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-12706-60, E-AB-12706-120, E-AB-12706-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: AGXT
Target Synonym: AGT; AGT1; Agxt; AGXT1; Alanine glyoxylate aminotransferase; Alanine glyoxylate aminotransferase3; Alanine--glyoxylate aminotransferase; EC 2.6.1.44; EC 2.6.1.51; Hepatic peroxisomal alanine glyoxylate aminotransferase; Hepatic peroxisomal alanine:glyoxylate aminotransferase; L alanine glyoxylate aminotransferase 1; MS773; PH1; Serine pyruvate aminotransferase; Serine--pyruvate aminotransferase; Serine--pyruvate aminotransferase; mitochondrial; Serine:pyruvate aminotransferase; SPAT; SPT; SPYA; TLH6
Research Areas: Cancer, Metabolism, Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: WB, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P21549
Background: Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene. This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1), also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.
Concentration: 0.6 mg/mL
Immunogen: Synthetic peptide of human AGXT
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000
Calculated MW: 43kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only