Product Description

AHCYL1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS71444-50, BS71444-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: AHCYL1 (S-adenosylhomocysteine hydrolase-like 1), also known as DCAL, IRBIT or PRO0233, is an endoplasmic reticμlum (ER) protein that is involved in amino acid biosynthesis. Expressed in dentritic blood cells (DCs), AHCYL1 functions to catalyze the H(2)O-dependent conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine, a reaction that uses NAD as a cofactor. Additionally, AHCYL1 contains a PDZ-binding domain and a PEST region through which it can interact with IP3R-I (inositol 1, 4, 5-trisphosphate (IP3) receptor-I), a protein involved in various signaling pathways. This interaction lowers the affinity of IP3R-1 for its substrate, IP3, thereby decreasing the rate of IP3-IP3R-I binding. AHCYL1 shares 100% homology with its mouse counterpart, indicating a highly conserved function between species. Two isoforms of AHCYL1 are expressed due to alternative splicing events.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: DCAL, IRBIT, XPVKONA, Adenosylhomocysteinase 2, AdoHcyase 2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of human AHCYL1.

Dilution: WB 1:500 - 1:2000
IHC 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: AHCYL1 polyclonal antibody detects endogenous levels of AHCYL1 protein.

Molecular Weight: ~ 59 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O43865

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only