Product Description

AIF Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS90041-50, BS90041-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: A key event in the apoptotic process is the opening of the mitochondrial permeability transition pore, an event that is regμlated by Bcl-2 family proteins, resμlting in the release of several proteins from the mitochondrial intermembrane space. Several of these proteins participate in apoptosis, including cytochrome c, procaspases 2, 3, and 9, and AIF (apoptosis-inducing factor). AIF has been shown to cause DNA fragmentation and chromatin condensation and to induce the release of cytochrome c and caspase-9 from mitochondria. Bcl-2 overexpression has been shown to prevent the release of AIF from mitochondria, but not to block its apoptogenic activity.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ICC, IHC, IP, FC

Alternate Names: AIFM1, AIFM1, AIFM1, Apoptosis inducing factor 1, mitochondrial, Apoptosis inducing factor, Apoptosis inducing factor, mitochondrion associated, 1, Apoptosis-inducing factor 1, CMTX4, COWCK, COXPD6, Harlequin, Hq, mAIF, MGC111425, MGC5706, mitochondrial, Neuropathy, axonal motor-sensory, with deafness and mental retardation, neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome), PDCD 8, PDCD8, Programmed cell death 8 (apoptosis inducing factor), Programmed cell death 8, Programmed cell death 8 isoform 1, Programmed cell death 8 isoform 2, Programmed cell death 8 isoform 3, Programmed cell death protein 8, Programmed cell death protein 8 mitochondrial, Programmed cell death protein 8 mitochondrial precursor, Programmed cell death protein 8 mitochondrial precursor, Striatal apoptosis inducing factor,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: recombinant protein

Dilution: WB:1:1, 000-1:5, 000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Purification: ProA affinity purified

Specificity: AIF polyclonal antibody detects endogenous levels of AIF protein.

Molecular Weight: ~ 67 kDa

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

SwissProt: O95831(Human) Q9Z0X1(Mouse) Q9JM53(Rat)

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only