Product Description

Aiolos (S386) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2508-50, BS2508-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Ikaros family members, including Ikaros and Helios, are nuclear factors that colocalize with DNA replication machinery components in higher-order chromatin structures and respond to signaling events, such as T cell activation. Helios and Ikaros bind to similar DNA sequences and they function as hemopoietic-specific transcription factors. Members of the Ikaros family contain zinc-finger domains that are involved in DNA-binding and in the formation of homodimers and heterodimers between Ikaros family members. Aiolos, also known as zinc finger protein Ikaros 3 or ZNFN1A3, is a 509 amino acid nuclear protein. Aiolos plays an important role in lymphocyte differentiation regμlation and, via this role, mutated Aiolos is implicated in leukemogenesis. Expressed in most tissues, Aiolos is predominantly found in spleen, thymus and peripheral blood leukocytes. Aiolos contains six C2H2-type zinc fingers, a motif commonly involved in nucleotide binding. Aiolos interacts with Ikaros family members, including Eos and Pegasus.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Phosphatidylinositol 3-kinase regμlatory subunit alpha, PI3-kinase regμlatory subunit alpha, PI3K regμlatory subunit alpha, PtdIns-3-kinase regμlatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regμlatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regμlatory subunit p85-alpha, PIK3R1, GRB1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human MYLK.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Aiolos (S386) polyclonal antibody detects endogenous levels of Aiolos (S386) protein.

Molecular Weight: ~ 50, 65 kDa

Pathway: Immune Cell Signaling, B cell receptor signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UKT9

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only