Product Description

AK2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS6319-50, BS6319-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Adenylate kinases 1-5 (designated AK1-5) are a set of enzymes that regμlate the phosphorylation state of intracellμlar adenine nucleotides, which are the principle high-energy phosphoryl-carrying molecμles in living cells. AKs influence metabolic signals, which include gene expression, ion channel activity and protein kinase-mediated signaling, by catalyzing phosphoryl transfer between adenine nucleotides (AMP, ADP, ATP). Inherited mutations leading to AK deficiencies in erythrocytes have been implicated in hemolytic anemia. AK2 is found in the mitochondria of liver and heart tissues and is the only AK that localizes to the mitochondrial intermembrane space. In apoptotic cells, AK2 is the only AK that translocates into the cytosol concomitantly with cytochrome c, suggesting that only intermembrane proteins are released from mitochondria during the early stages of apoptosis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Adenylate kinase 2, mitochondrial, AK 2, ATP-AMP transphosphorylase 2, ATP:AMP phosphotransferase, Adenylate monophosphate kinase, AK2, ADK2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human AK2.

Dilution: WB: 1:500~1:2000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: AK2 polyclonal antibody detects endogenous levels of AK2 protein.

Molecular Weight: ~ 32 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P54819

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only