Product Description

AKIRIN1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65445-50, BS65445-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous nμll D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regμlate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Horse, Sheep

Host: Rabbit

Applications: IHC-P

Alternate Names: AKIRIN 1, C1orf108, FLJ12666, OTTHUMP00000008669, RP11-781D11.2, STRF2, AKIR1_HUMAN.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human AKIRIN1:101-192/192

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: AKIRIN1 Polyclonal Antibody detects endogenous levels of AKIRIN1 protein.

Molecular Weight: 22kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9H9L7

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only