Product Description

ALIX Rabbit Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66311-50, MB66311-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Alix, a phylogenetically conserved cytosolic scaffold protein, contains an N-terminal Bro1 domain, a coiled-coil region and a C-terminal proline-rich domain. Originally identified as an ALG-2 (apoptosis-linked gene 2)-interacting protein involved in programmed cell death , Alix also regμlates many other cellμlar processes, such as endocytic membrane trafficking and cell adhesion through interactions with ESCRT (endosomal sorting complex required for transport) proteins, endophilins, and CIN85 (Cbl-interacting protein of 85 kDa). Alix has also been shown to be involved in the biogenesis of exosomes, small secreted vesicles that contribute to cell signaling. In addition, Alix interacts with Atg12-Atg3 to promote autophagy and endosomal fusion.

Category: Primary Antibody

Reactivity: Human, Rat, Hamster

Host: Rabbit

Applications: WB

Alternate Names: AIP1, ALIX, KIAA1375, Programmed cell death 6-interacting protein, PDCD6-interacting protein, ALG-2-interacting protein 1, ALG-2-interacting protein X, Hp95

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of human ALIX

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of ALIX protein.

Molecular Weight: ~ 100 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8WUM4

Product: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Research Use Only