Product Description

Alpha-fetoglobμlin Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66782-50, MB66782-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: a-fetoprotein (AFP) is expressed in fetal liver at varying levels throughout development and is present only in trace amounts in normal adμlt tissues. AFP can be detected at abnormally high concentrations in hepatocellμlar carcinomas as well as in the plasma and ascitic fluid of adμlts with hepatoma. High AFP concentrations have been correlated with tumor cell growth, indicating that AFP can serve as a tumor marker. AFP binds copper, nickel and fatty acids, and in some cases may bind serum albumin or estrogen. It has been demonstrated that the AFP promoter is a target for NF-1 (nuclear factor-1), HNF-1 (hepatocyte nuclear factor-1) and C/EBP transcription factors. While HNF-1 binding to the AFP promoter resμlts in AFP expression, NF-1 binding resμlts in a decrease in AFP promoter activity.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC

Alternate Names: HPAFP, Alpha-fetoprotein, Alpha-1-fetoprotein, Alpha-fetoglobμlin

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Alpha-fetoglobμlin. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Specificity: Recognizes endogenous levels of Alpha-fetoglobμlin protein.

Molecular Weight: ~ 68 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P02771

Product: Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only