AMPKα2 Polyclonal Antibody - RA21853

AMPKα2 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21853-50, RA21853-100

Citations, Manuals and MSDS Available upon request.

Background: protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2) Homo sapiens The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008],

Condition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB: 1:1000-2000

Alternative Names: PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 5563

Protein MW (KDa): 62

SWISS: P54646

Source: Rabbit

Research Use Only