AMPKα2 rabbit pAb - ES20835

AMPKα2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20835-50, ES20835-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008],

Alternate Name: PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase

Source: Rabbit

Applications: WB

Dilution: WB: 1:1000-2000

Reactivity: Human; Mouse; Rat

Immunogen: Recombinant Protein of AMPKα2

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Observed Band (KD): 62kD

Human Gene ID: 5563

Human SWISS Prot NO: P54646

Subcellular Location: Cytoplasm. Nucleus. In response to stress, recruited by p53/TP53 to specific promoters.

Research Use Only