Product Description

AMPKβ2 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21860-50, RA21860-100

Citations, Manuals and MSDS Available upon request.

Background: protein kinase AMP-activated non-catalytic subunit beta 2 (PRKAB2) Homo sapiens The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],

Condition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB: 1:1000-2000

Alternative Names: PRKAB2; 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 5565

Protein MW (KDa): 30

SWISS: O43741

Source: Rabbit

Research Use Only