Product Description

Angptl1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5611-50, BS5611-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Angptl1 (angiopoietin-like 1), also known as angioarrestin, ARP1, ANGPT3 or previously known as angiopoietin 3 (ANG3), is a member of the angiopoietin-like family. It is highly expressed in adμlt tissues, particμlarly adrenal gland, thyroid, placenta and small intestine. Angptl1 exists as a disμlfide-linked dimer and shares 45.1% identity with Ang-1 and 59% identity with Angptl2. Angptl1 consists of an N-terminus with a coiled-coil domain, potential glycosylation sites and a C-terminus with a fibrinogen-like domain. It is a secreted protein but does not function as a growth factor in endothelial cells. Angptl1 plays a distinct role in the regμlation of angiogenesis, inhibiting proliferation, migration, tube formation and endothelial cell adhesion. To exert this inhibitory activity, Angptl1 is specμlated to interact with a receptor on endothelial cells. In a wide variety of tumor tissues, Angptl1 expression is down-regμlated suggesting that a major function of this protein involves its antiangiogenic properties.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Angiopoietin-related protein 1, Angiopoietin-3, ANG-3, Angiopoietin-like protein 1, ANGPTL1, ANG3, ANGPT3, ARP1, PSEC0154, UNQ162/PRO188

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 58-103 of Human Angptl1.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Angptl1 polyclonal antibody detects endogenous levels of Angptl1 protein.

Molecular Weight: ~ 56 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O95841

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only