ANK3 Polyclonal Antibody
Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sizes: 50µl, 100µl
Catalogue Numbers: BS77975-50, BS77975-100
Swiss-Prot: Q12955
Host: Rabbit
ANK3 Polyclonal Antibody-BS77975
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Reactivity: Human, Mouse
Applications: IF/ICC
All Applications: IF/ICC,1:50 - 1:200
Background: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Specificity: Unmodification
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Immunofluorescence analysis of SH-SY5Y cells using ANK3 Rabbit pAb at dilution of 1:150. Blue: DAPI for nuclear staining., Immunofluorescence analysis of Neuro-2a cells using ANK3 Rabbit pAb at dilution of 1:200. Blue: DAPI for nuclear staining.
Alternative Name: MRT37; ANKYRIN-G
Immunogen: Recombinant fusion protein of human ANK3(NP_066267.2).
Modification: Unmodified
Conjugate: Unconjugated