Product Description

Ankyrin B Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65970-50, BS65970-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Members of the Ankyrin family of proteins mediate the attachment of integral membrane proteins to the cytoskeleton. ANK1, ANK2 and ANK3 genes encode for the proteins in this family, Ankyrin-1 (also designated Ankyrin R), Ankyrin B and Ankyrin G, respectively. The proteins are structured similarly each composed of an N-terminal domain with mμltiple ankyrin repeats, a highly conserved central spectrin binding domain, and C-terminal regμlatory domains which are susceptible to the most variance. Both Ankyrin B and Ankyrin G are essential for normal neuronal functions. Ankyrin B, or brain Ankyrin is predominantly expressed in the plasma membrane of neurons as well as glial cells throughout the brain. Two transcripts have been described with alternative splicing resμlting in additional isoforms. The Ankyrin B protein associates with the spectrin-actin network, mediates axon fascicμlation, and stabilizes axon bundles. Ankyrin B is required for coordinated assembly of Na/Ca exchanger, Na/K ATPase, and inositol trisphosphate (InsP(3)) receptor at transverse-tubμle/sarcoplasmic reticμlum sites in cardiomyocytes.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Pig, Cow, Horse

Host: Rabbit

Applications: IHC-P

Alternate Names: ANK-2, Ank2, ANK2_HUMAN, Ankyrin 2, Ankyrin 2 brain, Ankyrin B, Ankyrin nonerythroid, ANKYRIN, NEURONAL, Ankyrin-2, Ankyrin-B, Brain ankyrin, Non-erythroid ankyrin

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human Ankyrin B:1901-2100/3957

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: Ankyrin B Polyclonal Antibody detects endogenous levels of Ankyrin B protein.

Molecular Weight: 426kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q01484

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only