ANO3 rabbit pAb - ES18338

ANO3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES18338-50, ES18338-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015],

Source: Rabbit

Applications: WB

Dilution: WB 1: 500-2000

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human ANO3 AA range: 518-568

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 63982

Human SWISS Prot NO: Q9BYT9

Subcellular Location: Cell membrane; Multi-pass membrane protein. Shows an intracellular localization.

Research Use Only