Anti-Covid-19 Spike mAb IgG(03FC) - BT-CV00003

Anti-Covid-19 Spike mAb IgG(03FC)

Sizes: 100μg, 1mg

Catalogue Number: BT-CV00003-100μg, BT-CV00003-1mg

Citations, Manuals and MSDS Available upon request.

Background: Coronaviruses (CoVs) infect human and animals and cause varieties of diseases, including respiratory, enteric, renal, and neurological diseases. CoV uses its spike protein to recognize ACE2 as its receptors and mediate membrane fusion and virus entry into host cells(PMID: 32221306). Each monomer of trimeric S protein is about 180 kDa, and contains two subunits, S1 and S2,S1 recognizes and binds to host receptors, and subsequent conformational changes in S2 facilitate fusion between the viral envelope and the host cell membrane(PMID: 19198616). Although the amino acid sequences of the S-glycoprotein were found to be different between the various HCoV, the structures showed high similarity, but the best 3D structural overlap shared by SARS-CoV and SARS-CoV-2, consistent with the shared ACE2 predicted receptor (PMID: 32522207). The spike protein of CoVs can be a target for vaccine and therapeutic development (PMID: 19198616).

Research Areas: Others

Target Protein: SARS-CoV-2 S, 2019-nCoV S, Covid-19 S

Applications: WB,ELISA

Reactivity: Covid-19

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: SARS-CoV-2 Spike, 2019-nCoV Spike, Covid-19 Spike

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Synonyms: SARS-CoV-2 Spike, 2019-nCoV Spike, Covid-19 Spike

Research Use Only