Antithrombin III Monoclonal Antibody
Catalogue Numbers: MB66756-50, MB66756-100
Sizes: 50µl, 100µl
Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Swiss-Prot: P01008
Host: Mouse
Reactivity: Human, Rat
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation,complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Antithrombin III (ATIII),an extracellular plasma protein, is a crucial serine protease inhibitor that regulates the coagulation cascade in blood. The inhibitory activity of ATIII is amplified in the presence of heparin. ATIII inhibits Thrombin and Factors IX A,X A and XI A. Defects in the gene SERPINC1, which encodes for ATIII, can cause ATIII deficiency, an autosomal dominant disease, which is a risk factor for hereditary thrombophilia.
Purification and Purity: This antibody is purified through a protein G column.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of Antithrombin III protein.
Extra Notes: Western blot analysis of Antithrombin III expression in rat liver (A) whole cell lysates.
Bioworld Molecular Weight: ~ 60 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: AT3; Antithrombin-III; ATIII; Serpin C1
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Antithrombin III. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified