Product Description

ANTXR1 Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Sizes: 50µl, 100µl

Catalogue Numbers: BS71922-50, BS71922-100

Swiss-Prot: Q9H6X2

Host: Rabbit

ANTXR1 Polyclonal Antibody-BS71922

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse

Applications: WB, IF

All Applications: WB 1:500 - 1:2000
IF 1:50 - 1:100

Background: This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: ANTXR1 polyclonal antibody detects endogenous levels of ANTXR1 protein.

Bioworld Molecular Weight: 75kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of extracts of various cell lines, using ANTXR1 antibody at 1:1000 dilution., Immunofluorescence analysis of HeLa cell using ANTXR1 antibody. Blue: DAPI for nuclear staining.

Alternative Name: ATR; GAPO; TEM8

Immunogen: Recombinant protein of human ANTXR1

Modification: Unmodified

Conjugate: Unconjugated