Apaf-1 rabbit pAb - ES4108

Apaf-1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4108-50, ES4108-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Alternate Name: APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human APAF1. AA range:501-550

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 135kD

Human Gene ID: 317

Human SWISS Prot NO: O14727

Subcellular Location: Cytoplasm

Research Use Only