APBB1 Polyclonal Antibody - BT-AP14233

APBB1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14233-20, BT-AP14233-50, BT-AP14233-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimerandapos;s disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene productandapos;s nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimerandapos;s disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Research Areas: Neuroscience; Signal transduction

Target Protein: APBB1

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Amyloid beta A4 precursor protein-binding family B member 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O00213; Mouse: Q9QXJ1; Rat: P46933

Synonyms: Amyloid beta A4 precursor protein-binding family B member 1;Protein Fe65

GeneID: Human: 322

Research Use Only