Product Description

APOBR Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS60755-50, BS60755-100

Sizes: 50µl, 100µl

Swiss-Prot: Q0VD83

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, IHC

Background: ApoB48R (apolipoprotein B48 receptor), also known as apolipoprotein B-100 receptor, is a 1,088 amino acid protein that functions as a macrophage receptor by binding to apoB of dietary triglyceride-rich lipoproteins or to a similar apoB-like domain in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). ApoB48R may contribute necessary lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. Significantly elevated plasma triglyceride levels may cause apoB48R to be a factor in foam cell formation, endothelial dysfunction and atherothrombogenesis. ApoB48R also mediates the swift, high-affinity uptake of chylomicrons, HTG-VLDL and trypsinized VLDL lacking apoE in in vitro macrophages. Conserved in chimpanzee, dog, cow, mouse and rat, apoB48R is ubiquitously expressed in all tissues, except skeletal muscle, with high expression in lung and placenta, and low expression in brain and heart. ApoB48R is encoded by a gene that maps to human chromosome 16p11.2 and exists as three alternatively spliced isoforms.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: APOBR polyclonal antibody detects endogenous levels of APOBR protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of APOBR polyclonal antibody at 1:500 dilution
Lane 1: A549 whole cell lysate
Lane 2: MCF-7 whole cell lysate
Lane 3: PC12 whole cell lysate , Immunohistochemistry (IHC) analyzes of APOBR pAb in paraffin-embedded human rectum carcinoma tissue at 1:50,showing cytoplasmic staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Bioworld Molecular Weight: ~ 115 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Apolipoprotein B receptor; Apolipoprotein B-100 receptor; Apolipoprotein B-48 receptor; Apolipoprotein B48 receptor; apoB-48R; APOBR; APOB48R

Immunogen: A synthetic peptide corresponding to residues in Human APOBR

Conjugate: Unconjugated

Modification: Unmodified