Product Description

APP/β-Amyloid (phospho-T668) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4214-50, BS4214-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the β-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer’s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resμlting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid β/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer’s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Amyloid beta A4 protein, ABPP, APPI, Short name=APP, Alzheimer disease amyloid protein, Cerebral vascμlar amyloid peptide, Short name=CVAP, PreA4, Protease nexin-II, Short name=PN-II, N-APP, Soluble APP-alpha, Short name=S-APP-alpha, Soluble APP-beta, Short name=S-APP-beta, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, P3(42), P3(40), Gamma-secretase C-terminal fragment 59, Amyloid intracellμlar domain 59, Short name=AICD-59, Short name=AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellμlar domain 57, Short name=AICD-57, Short name=AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellμlar domain 50, AICD-50, AID(50), Gamma-CTF(50), APP, A4, AD, Amyloid-β, Amyloid β, Amyloidβ, β Amyloid, βAmyloid, Aβ

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human APP/β-Amyloid around the phosphorylation site of Threonine 668.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-APP/β-Amyloid (T668) polyclonal antibody detects endogenous levels of APP695 protein only when phosphorylated at Thr668 (or the corresponding position on other isoforms).

Molecular Weight: ~ 70 to140 kDa

Pathway: Neuronal and Glial Cell Marker Atlas, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P05067

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only