APP (Phospho-Thr668) Rabbit Polyclonal Antibody
Sizes: 20μL, 50μL, 100μL
Catalogue Numbers: BT-AP00505-20, BT-AP00505-50, BT-AP00505-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation| while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition| two of the peptides are antimicrobial peptides| having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Research Areas: Neuroscience; Signal transduction
Target Protein: APP
Applications: WB
Reactivity: Human, Mouse, Rat
Clonality: Polyclonal
Host: Rabbit
Isotype: IgG
Full Product Name: APP
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Storage: -20°C for 1 year
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
UniProt Accession: Human: P05067; Mouse: P12023; Rat: P08592
Synonyms: APP;Thr668; Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II; N-APP; Soluble APP-alpha; S-APP-alpha; Soluble APP-beta; S-APP-beta; C99; Beta-amyloid protein 42; Beta-APP42; Beta-amyloid protein 40; Beta-APP40; C83; P3;42; P3;40; C80; Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; AICD-59; AID;59; Gamma-CTF;59; Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; AICD-57; AID;57; Gamma-CTF;57; Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID;50; Gamma-CTF;50; C31;
GeneID: Human: 351; Mouse: 11820; Rat: 54226
Research Use Only