APPL1 rabbit pAb - ES1684

APPL1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES1684-50, ES1684-100

Citations, Manuals and MSDS Available upon request.

Background: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1) Homo sapiens The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008],

Alternate Name: APPL1; APPL; DIP13A; KIAA1428; DCC-interacting protein 13-alpha; Dip13-alpha; Adapter protein containing PH domain; PTB domain and leucine zipper motif 1

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human APPL1. AA range:121-170

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 80kD

Human Gene ID: 26060

Human SWISS Prot NO: Q9UKG1

Subcellular Location: Early endosome membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endosome. Cell projection, ruffle. Cytoplasmic vesicle, phagosome. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.

Research Use Only