AQP4 (P253) Polyclonal Antibody-BS3436

AQP4 (P253) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3436-50, BS3436-100

Sizes: 50µl, 100µl

Swiss-Prot: P55087

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: In skeletal muscle, AQP4 (aquaporin 4 also known as mercurial insensitive water channel), localizes to the sarcolemma of fast-twitch muscle fibers. Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0 through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: AQP4 (P253) polyclonal antibody detects endogenous levels of AQP4 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of AQP4 (P253) polyclonal antibody at 1:500 dilution
Lane 1: Hela cell lysate
Lane 2: Jurkat cell lysate
Lane 3: PC12 cell lysate
Lane 4: sp2/0 cell lysate, Immunohistochemistry (IHC) analyzes of AQP4 (P253) pAb in paraffin-embedded human lung carcinoma tissue.

Bioworld Molecular Weight: ~ 35 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Aquaporin 4; Aquaporin4; Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4; AQP4

Immunogen: Synthetic peptide, corresponding to amino acids 220-270 of Human AQP4.

Conjugate: Unconjugated

Modification: Unmodified