Product Description

Aquaporin 2 (Phospho-S256) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67427-50, BS67427-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Aquaporin 2 (AQP2) is a water transport protein that forms water channels in kidney tubμles and plays a predominant role in controlling organism water homeostasis . Members of the aquaporin family are mμltiple pass transmembrane proteins that form homotetramers to facilitate the flow of water across the plasma membrane. At least thirteen aquaporins have been indentified to date (AQP0 through AQP12) and together this family of small, hydrophobic proteins plays a role in an array of biological processes that include urine formation, cell motility, fertilization, cell junction formation and regμlation of overall water homeostasis . AQP2 tetramers form water channels that facilitate water transport and excretion in the kidney . This transport protein is localized to the plasma membrane is response to endocrine signaling. Posterior pituitary hormones arginine vasopressin (AVP) and ADH regμlate osmotic water cell permeability by triggering phosphorylation and subsequent exocytosis of AQP2. Mutations in the corresponding AQP2 gene cause a rare form of diabetes known as nephrogenic diabetes insipidus. This autosomal dominant disorder is characterized by abnormal water reabsorption by kidney tubμles due, in part, to either nonfunctional or mislocalized AQP2 protein.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Bovine, Dog, Pig, Sheep

Host: Rabbit

Applications: WB, IHC

Alternate Names: Aquaporin-2, AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD, Water channel protein for renal collecting duct

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Aquaporin 2 with a site at pS256. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of Aquaporin 2 with a site at pS256 protein.

Molecular Weight: ~ 26 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P41181

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only