Product Description

AR (phospho-S650) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4012-50, BS4012-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Androgens exhibit a wide range of effects on the development, maintenance and regμlation of male phenotype and reproductive physiology in males. The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind active testosterone (T) and dihydrotestosterone (DHT). The rates of association and dissociation of T are about 3 times more rapid than those of DHT. This difference in binding kinetics may account for the different physiological effects of T and DHT. Androgen binding resμlts in an at least 6-fold increase in androgen receptor stability.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human AR around the phosphorylation site of Serine 650.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-AR (S650) polyclonal antibody detects endogenous levels of Androgen Receptor protein only when phosphorylated at Ser650 .

Molecular Weight: ~ 110 kDa

Pathway: Nuclear Receptor Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P10275

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only