AR Polyclonal Antibody-BS90081

AR Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90081-50, BS90081-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P10275(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, ICC/IF, IHC, FC

All Applications: WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:100

Background: Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and male reproductive physiology. The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind the two biologically active androgens, testosterone (T) and dihydrotestosterone (DHT), with high and nearly identical affinities; however, the rates of association and dissociation of T are about three times more rapid than those of DHT. This difference has resulted in speculation as to whether these differences in binding kinetics could account for the different physiological effects of T and DHT. A striking feature of AR is its rapid degradation in the absence of ligand. It is now well established that androgen binding results in an at least six-fold increase in androgen stability and that ligand-induced stabilization of AR is highly androgen- specific.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: AR polyclonal antibody detects endogenous levels of AR protein.

Bioworld Molecular Weight: 99 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: ICC staining Androgen receptor in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS., ICC staining Androgen receptor in N2A cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: AR, AIS, ANDR, Androgen nuclear receptor variant 2, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Androgen receptor, androgen receptor splice variant 4b, AR, AR8, DHTR, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), Dihydrotestosterone receptor, HUMARA, HYSP1, KD, Kennedy disease (KD), NR3C4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nuclear receptor subfamily 3 group C member 4, SBMA, SMAX1, Spinal and bulbar muscular atrophy (SBMA), Spinal and bulbar muscular atrophy, Testicular Feminization (TFM), TFM,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified