Product Description

AREB6 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66977-50, MB66977-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ZEB family proteins are zinc-finger and homeobox domain containing transcription factors. There are two members in mammals, ZEB1 (δ-EF1, TCF8, AREB6) and ZEB2 (SIP1). ZEB1 and ZEB2 contain two separate zinc-finger domains and a homeodomain (1). While ZEB proteins mainly function as transcriptional suppressors, they are able to activate transcription, dependent on DNA-context and cell type . One of the targets suppressed by ZEB proteins is E-cadherin. Downregμlation of E-cadherin is one of the hallmarks of epithelial mesenchymal transition (EMT), a critical feature of normal embryonic development, which is also utilized by malignant epithelial tumors to spread beyond their origin . ZEB1 mutations are associated with posterior corneal dystrophy, and ZEB2 mutations were reported to be associated with Hirschsprung (HSCR) disease .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, FC

Alternate Names: AREB6, TCF8, Zinc finger E-box-binding homeobox 1, NIL-2-A zinc finger protein, Negative regμlator of IL2, Transcription factor 8, TCF-8

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human AREB6. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/5000), FC (1/10 - 1/50)

Specificity: Recognizes endogenous levels of AREB6 protein.

Molecular Weight: ~ 95 kDa

Pathway: Adherens Junction signaling, Wntβ catenin signaling.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P37275

Product: Mouse IgG1 kappa. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only