Product Description

ARFGEF2 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10565-50, MB10565-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q9Y6D5

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB,

All Applications: WB: 1/500-1/1000

Background: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 202 kDa; Observed MW: 202 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of ARFGEF2/BIG2 in rat testis lysates using ARFGEF2 antibody., Western blot analysis of ARFGEF2 in Hela, 293T lysates using ARFGEF2 antibody.

Alternative Name: BIG2; PVNH2; dJ1164I10.1

Immunogen: A synthetic peptide of human ARFGEF2

Conjugate: Unconjugated

Modification: Unmodified