Argonaute 2 Monoclonal Antibody-MB10566

Argonaute 2 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10566-50, MB10566-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q9UKV8

Host: Rabbit

Reactivity: Human

Applications: WB, ICC/IF, IP,

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20

Background: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). Can also upregulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and upregulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 97 kDa; Observed MW: 97 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunocytochemistry analysis of Argonaute 2 in HCT116 using Argonaute 2 antibody, and DAPI., Western blot analysis of Argonaute2 in K562, MCF-7, Hela lysates using Argonaute2 antibody.

Alternative Name: Ago 2; Argonaute 2; dAgo2; eIF2C 2; hAgo2; PPD

Immunogen: A synthetic peptide of human Argonaute-2

Conjugate: Unconjugated

Modification: Unmodified